:root {
  --ink: #09111f;
  --ink-soft: #283346;
  --muted: #667085;
  --paper: #fbfcfd;
  --white: #ffffff;
  --line: #dce4ea;
  --blue: #2563eb;
  --blue-soft: #eef4ff;
  --teal: #087f83;
  --teal-soft: #e5f6f5;
  --coral: #ff4e42;
  --coral-soft: #fff0ed;
  --violet: #6f49aa;
  --violet-soft: #f2ecfb;
  --amber: #d98912;
  --amber-soft: #fff5df;
  --purple: #7752a6;
  --purple-soft: #f4eefd;
  --stjude-red: #b40043;
  --shadow: 0 18px 60px rgba(23, 33, 48, 0.10);
  --radius: 8px;
  color-scheme: light;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
}

body {
  margin: 0;
  padding-bottom: 64px;
  background:
    radial-gradient(circle at 18% 18%, rgba(8, 127, 131, 0.08), transparent 28%),
    radial-gradient(circle at 82% 38%, rgba(255, 78, 66, 0.08), transparent 30%),
    var(--paper);
  color: var(--ink);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  font-size: 16px;
  line-height: 1.5;
}

a {
  color: inherit;
  text-decoration: none;
}

img,
svg {
  display: block;
}

.site-header {
  position: sticky;
  top: 0;
  z-index: 20;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 32px;
  min-height: 76px;
  padding: 14px clamp(20px, 4vw, 72px);
  background: rgba(251, 252, 253, 0.86);
  border-bottom: 1px solid rgba(220, 228, 234, 0.86);
  backdrop-filter: blur(18px);
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  font-weight: 800;
  line-height: 1.05;
}

.brand-mark {
  display: grid;
  place-items: center;
  width: 56px;
  height: 48px;
  border: 2px solid var(--ink);
  border-radius: 3px;
  color: var(--ink);
  font-size: 19px;
  letter-spacing: 0;
  line-height: 0.92;
}

.brand-name {
  font-size: 17px;
}

.institution-lockup,
.hero-affiliation,
.footer-institution {
  display: inline-flex;
  align-items: center;
}

.institution-lockup {
  gap: 10px;
  margin-right: auto;
  padding-left: 22px;
  border-left: 1px solid var(--line);
  color: var(--ink-soft);
  font-size: 13px;
  font-weight: 800;
  line-height: 1.15;
}

.institution-lockup img {
  width: 42px;
  height: 42px;
  border: 1px solid rgba(180, 0, 67, 0.20);
  border-radius: 50%;
  object-fit: cover;
}

.site-nav {
  display: flex;
  align-items: center;
  gap: clamp(18px, 3vw, 42px);
  color: var(--ink-soft);
  font-size: 14px;
  font-weight: 700;
}

.site-nav a {
  padding: 8px 0;
  border-bottom: 2px solid transparent;
}

.site-nav a:hover,
.site-nav a:focus-visible {
  border-color: var(--teal);
  outline: none;
}

.hero {
  position: relative;
  display: grid;
  grid-template-columns: minmax(0, 0.92fr) minmax(420px, 1.08fr);
  min-height: clamp(620px, 84vh, 820px);
  overflow: hidden;
  border-bottom: 1px solid var(--line);
}

.hero-copy {
  position: relative;
  z-index: 2;
  max-width: 770px;
  padding: clamp(50px, 7vw, 88px) 0 46px clamp(24px, 5vw, 76px);
}

.hero h1 {
  max-width: 760px;
  margin: 0;
  font-family: Georgia, "Times New Roman", serif;
  font-size: clamp(52px, 6.5vw, 96px);
  font-weight: 700;
  line-height: 0.92;
  letter-spacing: 0;
}

.hero p {
  max-width: 690px;
  margin: 28px 0 0;
  color: var(--ink-soft);
  font-size: clamp(19px, 2vw, 25px);
  line-height: 1.42;
}

.hero-affiliation {
  max-width: 610px;
  gap: 14px;
  margin-top: 24px;
  padding: 12px 14px;
  border: 1px solid rgba(180, 0, 67, 0.22);
  border-radius: var(--radius);
  background: rgba(255, 255, 255, 0.84);
  color: var(--ink-soft);
  font-size: 15px;
  font-weight: 750;
  box-shadow: 0 8px 30px rgba(9, 17, 31, 0.05);
}

.hero-affiliation img {
  flex: 0 0 auto;
  width: 58px;
  height: 58px;
  border: 1px solid rgba(180, 0, 67, 0.18);
  border-radius: 50%;
  object-fit: cover;
}

.hero-actions {
  display: grid;
  gap: 12px;
  margin-top: 34px;
}

.hero-action-row {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 12px;
}

.hero-action-label {
  min-width: 82px;
  color: var(--ink);
  font-size: 15px;
  font-weight: 850;
}

.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 52px;
  padding: 0 20px;
  border: 1.5px solid currentColor;
  border-radius: var(--radius);
  background: var(--white);
  font-size: 14px;
  font-weight: 800;
  box-shadow: 0 1px 0 rgba(9, 17, 31, 0.04);
  transition: transform 180ms ease, box-shadow 180ms ease, background 180ms ease;
}

.button::after,
.text-link::after {
  content: "";
  width: 9px;
  height: 9px;
  margin-left: 10px;
  border-top: 2px solid currentColor;
  border-right: 2px solid currentColor;
  transform: rotate(45deg);
}

.button:hover,
.button:focus-visible {
  transform: translateY(-2px);
  box-shadow: var(--shadow);
  outline: none;
}

.button.teal,
.accent-teal {
  color: var(--teal);
}

.button.blue,
.accent-blue {
  color: var(--blue);
}

.button.coral,
.accent-coral {
  color: var(--coral);
}

.button.violet,
.accent-violet {
  color: var(--violet);
}

.button.amber,
.accent-amber {
  color: var(--amber);
}

.button.purple,
.accent-purple {
  color: var(--purple);
}

.button.ink {
  color: var(--white);
  background: var(--ink);
  border-color: var(--ink);
}

.source-note {
  max-width: 610px;
  margin-top: 26px;
  padding: 15px 18px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(255, 255, 255, 0.78);
  color: var(--ink-soft);
  font-size: 14px;
  box-shadow: 0 8px 30px rgba(9, 17, 31, 0.05);
}

.source-note a {
  color: var(--teal);
  font-weight: 800;
}

.source-note a:hover,
.source-note a:focus-visible {
  color: var(--blue);
  outline: none;
}

.hero-visual {
  position: relative;
  min-height: 620px;
}

.hero-visual::before {
  position: absolute;
  inset: 0 auto 0 -18%;
  z-index: 1;
  width: 44%;
  content: "";
  background: linear-gradient(90deg, var(--paper) 0%, rgba(251, 252, 253, 0.76) 44%, rgba(251, 252, 253, 0) 100%);
}

.hero-visual img {
  width: 100%;
  height: 100%;
  min-height: 620px;
  object-fit: cover;
  object-position: center right;
}

.section {
  padding: clamp(54px, 7vw, 88px) clamp(20px, 4vw, 72px);
}

.section-heading {
  max-width: 760px;
  margin-bottom: 28px;
}

.section-heading.compact {
  max-width: 640px;
}

.section h2 {
  margin: 0;
  font-family: Georgia, "Times New Roman", serif;
  font-size: clamp(34px, 4.2vw, 58px);
  line-height: 1.02;
  letter-spacing: 0;
}

.section-heading p,
.workflow-intro p,
.about-section p {
  margin: 12px 0 0;
  color: var(--ink-soft);
  font-size: 18px;
}

.split-section {
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.62), rgba(251, 252, 253, 0.92));
}

.card-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 20px 32px;
}

.explorer-groups {
  display: grid;
  gap: 38px;
}

.explorer-group {
  display: grid;
  gap: 18px;
}

.group-heading {
  max-width: 720px;
}

.group-heading h3 {
  margin: 0;
  color: var(--ink);
  font-size: clamp(24px, 2.4vw, 34px);
  line-height: 1.12;
}

.group-heading p {
  margin: 8px 0 0;
  color: var(--ink-soft);
  font-size: 16px;
}

.pathogen-grid {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

.universal-grid {
  grid-template-columns: minmax(0, 0.64fr);
}

.feature-card,
.pipeline-card {
  display: flex;
  flex-direction: column;
  min-height: 100%;
  padding: 28px;
  border: 1.5px solid currentColor;
  border-radius: var(--radius);
  background: rgba(255, 255, 255, 0.84);
  box-shadow: 0 10px 34px rgba(22, 33, 48, 0.06);
}

.feature-card.accent-teal {
  background: linear-gradient(180deg, var(--white), var(--teal-soft));
}

.feature-card.accent-coral {
  background: linear-gradient(180deg, var(--white), var(--coral-soft));
}

.feature-card.accent-violet {
  background: linear-gradient(180deg, var(--white), var(--violet-soft));
}

.feature-card.accent-blue {
  background: linear-gradient(180deg, var(--white), var(--blue-soft));
}

.universal-card {
  position: relative;
}

.card-icon {
  display: grid;
  place-items: center;
  width: 58px;
  height: 58px;
  margin-bottom: 20px;
  border-radius: 50%;
  color: var(--white);
}

.card-icon svg {
  width: 38px;
  height: 38px;
  color: var(--white);
  fill: none;
  stroke: currentColor;
  stroke-linecap: round;
  stroke-linejoin: round;
  stroke-width: 2.2;
}

.feature-card h3,
.pipeline-card h3 {
  margin: 0;
  color: currentColor;
  font-size: 24px;
  line-height: 1.15;
}

.feature-card p,
.pipeline-card p {
  margin: 10px 0 0;
  color: var(--ink-soft);
}

.feature-card .data-source {
  margin-top: 14px;
  color: var(--muted);
  font-size: 14px;
  font-weight: 750;
}

.feature-card .data-source a {
  color: currentColor;
  text-decoration: underline;
  text-decoration-thickness: 1.5px;
  text-underline-offset: 3px;
}

.feature-card .data-source a:hover,
.feature-card .data-source a:focus-visible {
  color: var(--blue);
  outline: none;
}

.feature-card ul,
.pipeline-card ol {
  margin: 22px 0 0;
  padding: 0;
  color: var(--ink-soft);
  list-style: none;
}

.feature-card li,
.pipeline-card li {
  position: relative;
  margin: 8px 0;
  padding-left: 24px;
}

.feature-card li::before,
.pipeline-card li::before {
  position: absolute;
  left: 0;
  color: currentColor;
  content: "✓";
  font-weight: 800;
}

.text-link {
  display: inline-flex;
  align-items: center;
  width: fit-content;
  margin-top: auto;
  padding-top: 26px;
  color: currentColor;
  font-weight: 850;
}

.text-link + .text-link {
  margin-top: 8px;
  padding-top: 0;
}

.accent-teal .card-icon {
  background: var(--teal);
}

.accent-blue .card-icon {
  background: var(--blue);
}

.accent-coral .card-icon {
  background: var(--coral);
}

.accent-violet .card-icon {
  background: var(--violet);
}

.accent-amber .card-icon {
  background: var(--amber);
}

.accent-purple .card-icon {
  background: var(--purple);
}

.pipelines-section {
  background:
    linear-gradient(90deg, rgba(8, 127, 131, 0.07), transparent 34%),
    linear-gradient(270deg, rgba(119, 82, 166, 0.09), transparent 40%),
    var(--white);
  border-top: 1px solid var(--line);
  border-bottom: 1px solid var(--line);
}

.pipeline-layout {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 24px;
  max-width: 1080px;
}

.pipeline-card.accent-amber {
  background: linear-gradient(180deg, var(--white), var(--amber-soft));
}

.pipeline-card.accent-purple {
  background: linear-gradient(180deg, var(--white), var(--purple-soft));
}

.workflow-section {
  display: grid;
  grid-template-columns: minmax(220px, 0.36fr) minmax(0, 1fr);
  gap: 48px;
  align-items: start;
}

.workflow-intro h2 {
  margin: 0;
}

.workflow-track {
  display: grid;
  gap: 18px;
}

.workflow-row {
  display: grid;
  grid-template-columns: minmax(120px, 0.8fr) 62px minmax(120px, 0.8fr) 62px minmax(170px, 1.1fr) 62px minmax(150px, 0.9fr);
  align-items: center;
  gap: 12px;
}

.workflow-node {
  min-height: 74px;
  display: grid;
  align-content: center;
  padding: 15px 16px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: var(--white);
  color: var(--ink);
  font-weight: 850;
  box-shadow: 0 8px 28px rgba(22, 33, 48, 0.05);
}

.workflow-node.source {
  border-color: rgba(8, 127, 131, 0.36);
}

.workflow-node.pipeline {
  border-color: rgba(217, 137, 18, 0.42);
}

.workflow-node.explorer {
  border-color: rgba(255, 78, 66, 0.28);
}

.workflow-node.insight {
  border-color: rgba(111, 73, 170, 0.34);
}

.workflow-line {
  height: 1px;
  background: linear-gradient(90deg, var(--line), var(--muted));
}

.workflow-line::after {
  display: block;
  width: 9px;
  height: 9px;
  margin-top: -4px;
  margin-left: auto;
  border-top: 1.5px solid var(--muted);
  border-right: 1.5px solid var(--muted);
  content: "";
  transform: rotate(45deg);
}

.about-section {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 32px;
  align-items: center;
  background: var(--ink);
  color: var(--white);
}

.about-section p {
  max-width: 850px;
  color: rgba(255, 255, 255, 0.78);
}

@media (max-width: 1280px) {
  .card-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .universal-grid {
    grid-template-columns: 1fr;
  }
}

.site-footer {
  position: fixed;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 20;
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 20px;
  min-height: 56px;
  padding: 10px clamp(20px, 4vw, 72px);
  background: rgba(255, 255, 255, 0.92);
  border-top: 1px solid var(--line);
  color: var(--ink-soft);
  backdrop-filter: blur(18px);
}

.footer-brand {
  color: var(--ink);
}

.site-footer p {
  margin: 0;
}

.footer-institution {
  justify-content: center;
  gap: 9px;
  color: var(--ink-soft);
  text-align: center;
}

.footer-institution img {
  width: 24px;
  height: 24px;
  border: 1px solid rgba(180, 0, 67, 0.20);
  border-radius: 50%;
  object-fit: cover;
}

.footer-links {
  display: flex;
  gap: 24px;
  font-weight: 750;
}

.footer-links a:hover,
.footer-links a:focus-visible {
  color: var(--teal);
  outline: none;
}

@media (max-width: 1040px) {
  .site-header {
    align-items: flex-start;
    flex-direction: column;
    gap: 14px;
  }

  .institution-lockup {
    margin-right: 0;
    padding-left: 0;
    border-left: 0;
  }

  .hero {
    grid-template-columns: 1fr;
  }

  .hero-copy {
    max-width: none;
    padding-right: clamp(20px, 5vw, 76px);
  }

  .hero-visual {
    min-height: 360px;
    margin-top: -46px;
  }

  .hero-visual::before {
    inset: -2px 0 auto 0;
    width: 100%;
    height: 38%;
    background: linear-gradient(180deg, var(--paper), rgba(251, 252, 253, 0));
  }

  .hero-visual img {
    min-height: 360px;
  }

  .card-grid,
  .pipeline-layout,
  .workflow-section {
    grid-template-columns: 1fr;
  }

  .workflow-row {
    grid-template-columns: 1fr;
    gap: 8px;
  }

  .workflow-line {
    width: 1px;
    height: 30px;
    margin-left: 20px;
    background: linear-gradient(180deg, var(--line), var(--muted));
  }

  .workflow-line::after {
    margin-top: 22px;
    margin-left: -4px;
    transform: rotate(135deg);
  }

  .site-footer {
    align-items: flex-start;
    flex-direction: column;
  }
}

@media (max-width: 680px) {
  body {
    padding-bottom: 176px;
  }

  .site-nav {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    width: 100%;
    gap: 6px 18px;
  }

  .brand-name {
    font-size: 15px;
  }

  .hero {
    min-height: auto;
  }

  .hero-copy {
    padding-top: 44px;
  }

  .hero h1 {
    font-size: clamp(38px, 12.8vw, 50px);
  }

  .hero-actions {
    display: grid;
    grid-template-columns: 1fr;
  }

  .hero-action-row {
    display: grid;
    grid-template-columns: 1fr;
  }

  .hero-action-label {
    min-width: 0;
  }

  .hero-affiliation {
    align-items: flex-start;
  }

  .hero-affiliation img {
    width: 48px;
    height: 48px;
  }

  .button {
    justify-content: space-between;
    width: 100%;
  }

  .feature-card,
  .pipeline-card {
    padding: 22px;
  }

  .about-section {
    grid-template-columns: 1fr;
  }

  .footer-links {
    flex-wrap: wrap;
  }
}

@media (prefers-reduced-motion: reduce) {
  *,
  *::before,
  *::after {
    scroll-behavior: auto !important;
    transition-duration: 0.01ms !important;
  }
}