Respiratory Virus Evolution Atlas

Pathogen-specific Shiny apps and reproducible pipelines for tracking amino acid variation, clade evolution, and lineage patterns across respiratory viruses and Nextclade3-supported pathogens.

Developed by Center for Applied Bioinformatics @ St. Jude Children's Research Hospital.
RSV and COVID data are downloaded from Nextstrain and processed by NextAA. Human influenza data are downloaded from GISAID and processed by FLUAA.

Explore Amino Acid Variation

Public Shiny applications for scanning clade-aware amino acid changes across respiratory virus datasets and other Nextclade3-supported pathogens.

Pathogen-specific Explorers

Dedicated apps for RSV, SARS-CoV-2, and human Influenza datasets.

RSV Explorer

Visualize amino acid variation across RSV clades and lineages.

Data source: Nextstrain

Total Sequences
66,046
Countries Represented
91
Time Span
1941 - 2026
  • Nextstrain-derived clade context
  • Mutation patterns over time
  • Sequence and metadata filters

COVID Explorer

Track amino acid changes across SARS-CoV-2 clades.

Data source: Nextstrain

Total Sequences
9,421,502
Countries Represented
128
Time Span
2019 - 2026
  • Nextstrain-derived clade context
  • Variant summaries by position
  • Lineage and temporal views

FLU Explorer

Explore amino acid variation in human influenza viruses.

Data source: GISAID

Total Sequences
565,521
Countries Represented
212
Time Span
1918 - 2026
  • GISAID-derived flu sequence data
  • Subtype and clade comparisons
  • Research-ready visual summaries

Universal Explorer

A flexible viewer for NextAA outputs from any supported Nextstrain dataset.

AAExplorer

Universal Explorer for NextAA outputs from any Nextstrain dataset supported by Nextclade3. Current data: Chikungunya virus.

Data source: Nextstrain

Total Sequences
8,842
Countries Represented
108
Time Span
1952 - 2025
  • Universal NextAA output viewer
  • Works across Nextclade3-supported pathogens
  • Designed for Nextstrain-available datasets
Featured AI Setup Skill

Install RVE Atlas Apps With an AI Agent

The RVEAtlas Skill helps AI coding agents install and run COVIDExplorer, RSVExplorer, FLUExplorer, and AAExplorer locally. It can preview the setup with a dry run, download app code and release data, install missing R packages, and launch the selected Shiny app in a browser.

Ask your coding agent

Use the RVEAtlas skill to install and run RSVExplorer locally. Install it into ~/RVEAtlasApps. Start with a dry run, then do the real install if the dry run looks correct.

  • Supports macOS and Linux
  • Uses R 4.0+, Git, and Python 3
  • Installs one selected Shiny app at a time

Analysis Pipelines

Workflows for transforming global sequence resources into amino acid annotations and clade-aware explorer inputs.

NextAA Pipeline

Processes Nextstrain data for Nextclade3-supported pathogens into standardized amino acid variation outputs for AAExplorer and pathogen-specific explorers.

  1. Download from Nextstrain
  2. Standardized processing
  3. Amino acid annotation
  4. Explorer-ready exports
View Pipeline

FLUAA Pipeline

Processes GISAID human influenza data into amino acid variation summaries for the FLU Explorer.

  1. Download from GISAID
  2. Customized flu processing
  3. Amino acid annotation
  4. Explorer-ready exports
View Pipeline

Data Sources & Workflow

From global sequence datasets to accessible visual summaries for pathogen evolution research.

Nextstrain
NextAA
RSV, COVID & universal AAExplorer
Research Context
GISAID
FLUAA
FLU Explorer
Research Context

Built for Pathogen Evolution Research

RVE Atlas brings together public visualization apps and processing pipelines so researchers can move quickly from clade context to amino acid variation patterns across COVID, RSV, human influenza, and Nextstrain pathogens supported by Nextclade3.

Start Exploring