Respiratory Virus Evolution Atlas

One unified Shiny app and a reproducible pipeline for tracking amino acid variation, clade evolution, and lineage patterns across respiratory viruses and Nextclade3-supported pathogens — switch pathogens from a single interface.

Developed by Center for Applied Bioinformatics @ St. Jude Children's Research Hospital.
Explore by pathogen: RSV COVID Influenza CHIKV
Pipeline: NextAA
Local setup: AI Agent Skill
RSV and COVID data are downloaded from Nextstrain, and human influenza data from GISAID — all processed by NextAA.

Explore Amino Acid Variation

One public Shiny application for scanning clade-aware amino acid changes across respiratory virus datasets and other Nextclade3-supported pathogens — pick a pathogen from the same interface.

One Dedicated App, Pathogen-Specific Configurations

Explore RSV, SARS-CoV-2, and human/avian influenza datasets in one dedicated app.

RSV

Visualize amino acid variation across RSV clades and lineages.

Data source: Nextstrain

Total Sequences
66,046
Countries Represented
92
Time Span
1941 - 2026
  • Nextstrain-derived clade context
  • Mutation patterns over time
  • Sequence and metadata filters

COVID

Track amino acid changes across SARS-CoV-2 clades.

Data source: Nextstrain

Total Sequences
9,421,502
Countries Represented
128
Time Span
2019 - 2026
  • Nextstrain-derived clade context
  • Variant summaries by position
  • Lineage and temporal views

Influenza

Explore amino acid variation in human influenza viruses.

Data source: GISAID

Total Sequences
622,939
Countries Represented
228
Time Span
1918 - 2026
  • GISAID-derived flu sequence data
  • Subtype and clade comparisons
  • Research-ready visual summaries

Universal mode applicable to other pathogens

A flexible viewer for NextAA outputs from any supported Nextstrain dataset.

CHIKV

Universal Exploreriation for NextAA outputs from any Nextstrain dataset supported by Nextclade3. Current data: Chikungunya virus.

Data source: Nextstrain

Total Sequences
8,871
Countries Represented
109
Time Span
1952 - 2026
  • Universal NextAA output viewer
  • Works across Nextclade3-supported pathogens
  • Designed for Nextstrain-available datasets
Featured AI Setup Skill

Install RVE Atlas With an AI Agent

The RVEAtlas Skill helps AI coding agents install and run RVE Atlas locally — one app covering COVID, RSV, human influenza, and other pathogens (e.g. CHIKV) under a universal configuration. It can preview the setup with a dry run, download the app code and release data, install missing R packages, and launch the app in a browser.

Ask your coding agent

Use the RVEAtlas skill to install and run RVE Atlas locally. Install it into ~/RVEAtlas. Start with a dry run, then do the real install if the dry run looks correct.

  • Supports macOS and Linux
  • Uses R 4.0+, Git, and Python 3
  • One app — all pathogens included

Analysis Pipeline

The workflow that transforms global sequence resources into amino acid annotations and clade-aware explorer inputs.

  1. Download from Nextstrain / GISAID (FLU)
  2. Standardized processing
  3. Amino acid annotation
  4. Explorer-ready exports

Data Sources & Workflow

From global sequence datasets to accessible visual summaries for pathogen evolution research.

Nextstrain/GISAID
NextAA
RVEAtlas · RSV, COVID, Influenza & CHIKV
Research Context

Built for Pathogen Evolution Research

RVE Atlas brings together one public visualization app and a processing pipeline so researchers can move quickly from clade context to amino acid variation patterns across COVID, RSV, human influenza, and Nextstrain pathogens supported by Nextclade3.

Start Exploring